A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 99-14-9, Name is Propane-1,2,3-tricarboxylic acid, molecular formula is C6H8O6. In an article, author is Reddy, C. B. Rajashekar,once mentioned of 99-14-9, Name: Propane-1,2,3-tricarboxylic acid.
HDAC and NF-kappa B mediated cytotoxicity induced by novel N-Chloro beta-lactams and benzisoxazole derivatives
Novel N-chloro a-Lactam and benzisoxazole derivatives were successfully synthesized with excellent yields (92-96%) under simple and mild reaction conditions. The beta-lactams as a class acquired importance since the discovery of penicillin which contains beta-lactam unit as an essential structural feature of its molecule, this interest continued unabated because of the therapeutic importance of beta-lactam antibiotics. In silico studies of the compounds with cancer drug target enzymes showed the inhibition of HDAC (Histone Deacetylase) and NF-kappa B (nuclear factor kappa-light-chain-enhancer of activated B cells) significantly. The compounds were then investigated for the inhibitory potential against the same enzymes in vitro. NF-kappa B inhibition was investigated by trans activation assay using HEK293/NF-kappa B-luc cells. Overall, the synthesized compounds induce the cancer cell toxicity by restraining the NF-kappa B transcription factor mediated by HDAC inhibition and thus the compounds act as dual inhibitors. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics