Chemistry, like all the natural sciences, Category: Benzisoxazole, begins with the direct observation of nature¡ª in this case, of matter.536-66-3, Name is 4-Isopropylbenzoic acid, SMILES is C1=CC(=CC=C1C(C)C)C(O)=O, belongs to Benzisoxazole compound. In a document, author is MEWSHAW, RE, introduce the new discover.
EXAMINATION OF THE D(2)/5-HT(2) AFFINITY RATIOS OF RESOLVED 5,6,7,8,9,10-HEXAHYDRO-7,10-IMINOCYCLOHEPT[B]INDOLES – AN ENANTIOSELECTIVE APPROACH TOWARD THE DESIGN OF POTENTIAL ATYPICAL ANTIPSYCHOTICS
Enantiomers of several N-substituted 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles were obtained by the resolution of 2-fluoro-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole and 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole followed by N-alkylation. These, as well as the racemates, were evaluated for their affinity for the 5-HT2 and D2 receptors. Those compounds possessing the 7S,10R stereochemistry were consistently recognized by the 5-HT2 and D2 receptors as the eutomer. 2-Fluoro-11-[4-(4-fluorophenyl)-4-oxobutyl]-5,6,7,8,9,10-hexahydro-7S,10R-iminocyclohept[b]indole [(7S,10R)-8] had the highest affinity for the 5-HT2 receptor (K(i) = 0.80 nM), while its distomer (7R,10S)-8 was the most selective member of this class of bridged gamma-carbolines (D2/5-HT2 = 562). Incorporation of a benzoyl or isosteric benzisoxazole moiety tethered by a four-carbon spacer to a bridged gamma-carboline nucleus, possessing the 7S,10R absolute configuration, produced high affinity ligands for the 5-HT2 and D2 receptors.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 536-66-3. Category: Benzisoxazole.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics