Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Organic Letters called Palladium-Catalyzed Site-Selective Amidation of Dichloroazines, Author is Young, Ian S.; Glass, Anna-Lena; Cravillion, Theresa; Han, Chong; Zhang, Haiming; Gosselin, Francis, which mentions a compound: 442903-28-8, SMILESS is ClC1=C(C(=O)OC)C(=CC=N1)Cl, Molecular C7H5Cl2NO2, Recommanded Product: Methyl 2,4-dichloronicotinate.
A highly site-selective amidation reaction of substituted 2,4-dichloroazines is reported. Palladium acetate/1,1′-bis(diphenylphosphino)ferrocene (dppf) was identified as the optimal catalyst system, producing >99:1 C-2/C-4 selectivity for most examples. The generality of this transformation was demonstrated through a survey of a diverse amide/substituted 2,4-dichloroazine scope, leading to the preparation of the desired C-2 amidated products in good to excellent yields.
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics