Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 99189-60-3, Name is 2-[1-(2-Amino-2-oxoethyl)cyclohexyl]acetic Acid, molecular formula is C10H17NO3. In an article, author is Vanjari, Rajeshwer,once mentioned of 99189-60-3, Computed Properties of C10H17NO3.
Ring Expansion and 1,2-Migration Cascade of Benzisoxazoles with Ynamides: Experimental and Theoretical Studies
Demonstrated herein is an Au-I-catalyzed annulation of sulfonyl-protected ynamides with substituted 1,2-benzisoxazoles for the synthesis of E-benzo[e][1,3]oxazine derivatives. The transformation involves the addition of benzisoxazole to the gold-activated ynamide, ring expansion of the benzisoxazole fragment to provide an alpha-imino vinylic gold intermediate, and 1,2-migration of the sulfonamide motif to the masked carbene center to deliver the respective ring-expanded benzo[e][1,3]oxazine of predominant E configuration. A trapping experiment justifies the participation of the alpha-imino masked gold carbene. DFT computations also support the hypothesized mechanism and rationalize the product stereoselectivity.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics