The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Furoic hydrazide( cas:3326-71-4 ) is researched.Electric Literature of C5H6N2O2.Chalenko, N.; Demchenko, A.; Syrova, G. published the article 《Synthesis of potential antiexudative preparations for 2-((4-amino-5-(furan-2-yl)-1,2,4-triazole-(4h)-3-yl)-sulfanyl)-N-acetamide series》 about this compound( cas:3326-71-4 ) in ScienceRise: Pharmaceutical Science. Keywords: antiexudative antiinflammatory analgesic. Let’s learn more about this compound (cas:3326-71-4).
The aim of the study was to synthesize new potential biol. active substances of derivatives of 2-((4-amino-5-(furan-2-yl)-1,2,4-triazole(4H)-3-yl)-sulfanyl)-N acetamides and determination of their structure, physico-chem. properties and anti-exudative activity (AEA). Reactions were started with furan-2-carboxylic acid hydrazide with carbon disulfide in Et alc. in the presence of potassium hydroxide to form potassium dithiocarbazinate intermediate, followed by cyclical condensation with excess hydrazine, yielding tiotriazole (1) as a white solid with a good yield. Twenty-one new compounds were synthesized in the series of derivatives of 2-((4-amino-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl) sulfanyl)-N-acetamides, their phys. and chem. characteristics have been established. The structure of the synthesized compounds is confirmed by data from elemental anal., 1H NMR spectra and chromatog. mass spectrometry. Fifteen compounds have shown antiexudative activity, among the leaders were identified seven compounds: 3.1, 3.2, 3.5, 3.9, 3.11, 3.12, 3.19, which significantly suppressed swelling by 81.5 %; 61.1 %; 70.3 %; 55.5 %; 62.9 %; 53.0 %, resp., and significantly exceeded the activity of sodium diclofenac (44 %).
From this literature《Synthesis of potential antiexudative preparations for 2-((4-amino-5-(furan-2-yl)-1,2,4-triazole-(4h)-3-yl)-sulfanyl)-N-acetamide series》,we know some information about this compound(3326-71-4)Electric Literature of C5H6N2O2, but this is not all information, there are many literatures related to this compound(3326-71-4).
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics