Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Name: Ammonium oxalate1113-38-8, Name is Ammonium oxalate, SMILES is O=C([O-])C([O-])=O.[NH4+].[NH4+], belongs to Benzisoxazole compound. In a article, author is He, Guangchao, introduce new discover of the category.
Design, synthesis and biological evaluation of N-hydroxy- aminobenzyloxyarylamide analogues as novel selective kappa opioid receptor antagonists
Aminobenzyloxyarylamide derivatives la-i and 2a-t were designed and synthesized as novel selective kappa opioid receptor (KOR) antagonists. The benzoyl amide moiety of LY2456302 was changed into N-hydroxybenzamide and benzisoxazole-3(2H)-one to investigate whether it could increase the binding affinity or selectivity for KOR. All target compounds were evaluated in radioligand binding assays for opioid receptor binding affinity. These efforts led to the identification of compound lc (kappa K-i = 179.9 nM), which exhibited high affinity for KOR. Moreover, the selectivity of KOR over MOR and DOR increased nearly 2-fold and 7-fold, respectively, compared with ( +/- )LY2456302.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 1113-38-8. Name: Ammonium oxalate.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics