Heterocyclic Building Blocks-Benzisoxazole

Wrubel, Juergen published an article on January 31 ,1980. The article was titled 《2-Substituted 5-amino-1,2-benzisoxazoles》, and you may find the article in Zeitschrift fuer Chemie.SDS of cas: 65685-50-9 The information in the text is summarized as follows:

Nitration of benzisoxazoles I (R = OH, Cl; R1 = H) gave I (R = OH, Cl; R1 = NO2), and reaction with Br or SO2Cl2 gave I (R = OH, Cl; R1 = Br, Cl). Reduction of I (R = OH, R1 = NO2) with SnCl2 gave I (R = OH, R1 = NH2), which was diazotized and coupled with aromatic amines or phenols to give the azo dyes I (R = OH, R4 = 4-Me2NC6H4N:N, 2-hydroxy-1-naphthylazo). After reading the article, we found that the author used 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9SDS of cas: 65685-50-9)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.SDS of cas: 65685-50-9The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The author of 《Central effects of some new derivatives of benzoxazolin-2-one and 3-hydroxybenzisoxazole》 were Kolasa, Krystyna. And the article was published in Acta Poloniae Pharmaceutica in 1979. Recommanded Product: 65685-50-9 The author mentioned the following in the article:

The title compounds I (R = H or Br; R1 = H, Ac, or CO2Et), II (R = H or Br)and III (R = H or Br) tested in mice at their 1/5, 1/10, 1/20, and 1/40 LD50 dose showed a weak myorelaxant effect and weak inhibitory activity on the central nervous system. In the part of experimental materials, we found many familiar compounds, such as 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Recommanded Product: 65685-50-9)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.Recommanded Product: 65685-50-9

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Ferraris, Dana; Duvall, Bridget; Ko, Yao-Sen; Thomas, Ajit G.; Rojas, Camilo; Majer, Pavel; Hashimoto, Kenji; Tsukamoto, Takashi published an article in Journal of Medicinal Chemistry. The title of the article was 《Synthesis and Biological Evaluation of D-Amino Acid Oxidase Inhibitors》.Application of 65685-50-9 The author mentioned the following in the article:

D-Amino acid oxidase (DAAO) catalyzes the oxidation of D-amino acids including D-serine, a full agonist at the glycine site of the NMDA receptor. A series of benzo[d]isoxazol-3-ol derivatives were synthesized and evaluated as DAAO inhibitors. Among them, 6-chlorobenzo[d]isoxazol-3-ol (CBIO) potently inhibited DAAO with an IC50 in the submicromolar range. Oral administration of CBIO in conjunction with D-serine enhanced the plasma and brain levels of D-serine in rats compared to the oral administration of D-serine alone. In the experiment, the researchers used 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Application of 65685-50-9)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. Application of 65685-50-9 The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In 1980,Acta Poloniae Pharmaceutica included an article by Domagalina, Eugenia; Gaj, Barbara; Slawik, Tomasz. Recommanded Product: 5-Bromobenzo[d]isoxazol-3(2H)-one. The article was titled 《Arylsulfonyl and sulfanilyl derivatives of benzoxazoles and benzisoxazoles》. The information in the text is summarized as follows:

Benzoxazoles I (R = Cl, Br, R1 = H; R = H, R1 = Cl, Br, SO2NH2; R = Cl, Br, R1 = SO2NH2) and benzisoxazoles II (R = H, Cl, Br, SO2NH2) were prepared in 33-74% yields by treating 2-benzoxazolinones or 3-hydroxybenzisoxazoles, resp., with 4-AcNHC6H4SO2Cl in dioxane containing some Et3N. Similarly, 5-, 6-, and 7-amino-2-benzoxazolinone yielded III. I and III were deacetylated with HCl-EtOH; under similar conditions II yielded sulfanilic acid and the starting benzisoxazole derivative After reading the article, we found that the author used 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Recommanded Product: 5-Bromobenzo[d]isoxazol-3(2H)-one)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.Recommanded Product: 5-Bromobenzo[d]isoxazol-3(2H)-oneThe benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Uno, Hitoshi; Kurokawa, Mikio published their research in Chemical & Pharmaceutical Bulletin on February 28 ,1978. The article was titled 《Studies on 3-substituted 1,2-benzisoxazole derivatives. IV. Rearrangement of N-substituted 2H-1,2-benzisoxazolin-3-one to 2-substituted 2H-1,3-benzoxazin-4-one》.Recommanded Product: 5-Bromobenzo[d]isoxazol-3(2H)-one The article contains the following contents:

The base catalyzed ring expansion of 2-substituted 2H-1,2-benzisoxazolin-3-ones I (R = Ph, CO2Me, COPh, COMe, CCH, R1 = H; R = R1 = Ph; R = CO2Et, R1 = Me) to 2-substituted 2H-1,3-benzoxazin-4-ones II occurred during the alkylation of hydroxy-1,2-benzisoxazole. In the part of experimental materials, we found many familiar compounds, such as 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Recommanded Product: 5-Bromobenzo[d]isoxazol-3(2H)-one)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.Recommanded Product: 5-Bromobenzo[d]isoxazol-3(2H)-one

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

《New synthesis of 1,2-benzisoxazole derivatives》 was written by Kalkote, Uttam R.; Goswami, Das D.. Computed Properties of C7H4BrNO2 And the article was included in Australian Journal of Chemistry on August 31 ,1977. The article conveys some information:

N-Phenylsalicylohydroxamic acids (I, R = H, Cl, Br, I) were treated with SOCl2 in the presence of pyridine in anhydrous ether at 0° to give II (via III). IV (R3 = H, OH, Me; R2 = H, Me, Cl, Br, etc.) were similarly treated to give V. In addition to this study using 5-Bromobenzo[d]isoxazol-3(2H)-one, there are many other studies that have used 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Computed Properties of C7H4BrNO2) was used in this study.

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.Computed Properties of C7H4BrNO2The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Computed Properties of C7H4BrNO2On October 31, 1978 ,《Acylation of benzoxazolin-2-ones and 3-hydroxy-1,2-benzisoxazoles》 appeared in Polish Journal of Pharmacology and Pharmacy. The author of the article were Domagalina, Eugenia; Slawik, Tomasz. The article conveys some information:

5-Bromo- and 5,7-dibromobenzoxazolin-2-ones were acylated with Ac2O, R1C6H4COCl (R1 = H, 2-Cl, 4-NO2), and R2O2CCl (R2 = Me, Et) to give primarily N-acylated products I (Brn = 5-Br, 5,7-Br2; R3 = Me, R1C6H4, R2O). The isomeric brominated 3-hydroxy-1,2-benzisoxazoles were predominantly O-acylated to give II (R3 the same as above). Exceptions were benzoxazole III and benzisoxazolinones IV (Brn = H, 5-Br, 5,7-Br2; R3 = R2O). IV (Brn = H, 5-Br; R3 = EtO) were the strongest central nervous system depressants and they also showed anticonvulsant activity. 5-Bromo-3-hydroxy-1,2-benzisoxazole and IV (Brn = H, R3 = EtO) had significant analgesic activity. In the experiment, the researchers used many compounds, for example, 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Computed Properties of C7H4BrNO2)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.Computed Properties of C7H4BrNO2

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

《Synthesis, evaluation of analgesic and anti-inflammatory activities of substituted 1,2-benzoxazolone and 3-chloro-1,2-benzoxazole derivatives》 was published in International Journal of Pharmaceutical Sciences and Research in 2015. These research results belong to Kiran, B. Ravi; Vijayakumar, G. R.; Bharath, H. S.; Sivakumar, R.; Sindhu, S.; Prakash, M. Shet. Reference of 5-Bromobenzo[d]isoxazol-3(2H)-one The article mentions the following:

Herein method for the synthesis of substituted 1,2-benzoxazolone I [R1 = H, NO2, Br; R2 = H, Me, F; R3 = H, NO2, F] and 3-chloro-1,2-benzoxazole derivatives II [R1 = H, NO2, Br; R2 = H, Me, F; R3 = H, NO2, F] was described. A new scheme was adapted for the construction of 1,2-benzoxazole ring from salicylic acid and its derivatives which leads to the formation of series of methyl-2-hydroxy-5-bromo benzoate, Me 2-hydroxybenzoates and N,2-dihydroxybenzamides substituted title compounds Synthesized compounds were characterized by IR, 1H-NMR and Mass spectral anal. Spectral data confirmed the compounds formation. Final compounds I and II were screened for their in-vivo analgesic activity by acetic acid induced writhing method in rats and anti-inflammatory activity by carrageenan-induced paw edema model. Among the compounds screened compound I [R1, R2, R3 = H] and compound II [R1, R2 = H; R3 = NO2] showed good analgesic activity of about 45% (writhing mean 8.9) and 54% (writhing mean 7.5) inhibition resp. at 5 mg/Kg po dosage. Compounds I [R1 = NO2; R2, R3 = H] and II [R1 = NO2; R2, R3 = H] (both having inhibition edema of 66.1%) showed significant anti-inflammatory activity. Other derivatives exhibited moderate to good analgesic and anti-inflammatory activities. The experimental process involved the reaction of 5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9Reference of 5-Bromobenzo[d]isoxazol-3(2H)-one)

5-Bromobenzo[d]isoxazol-3(2H)-one(cas: 65685-50-9) belongs to benzisoxazole.The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. Reference of 5-Bromobenzo[d]isoxazol-3(2H)-one The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics