Saeedi, Mina et al. published their research in Letters in Drug Design & Discovery in 2021 | CAS: 334017-34-4

5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. Benzisoxazoles are currently the most important building blocks in drug discovery, with a high number of positive hits encountered in biological screens of this heterocycle and its derivatives. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on. Recommanded Product: 334017-34-4

Design and Synthesis of Novel 5-Arylisoxazole-1,3,4-thiadiazole Hybrids as α-Glucosidase Inhibitors was written by Saeedi, Mina;Eslami, Azadeh;Mirfazli, Seyedeh Sara;Zardkanlou, Mahsa;Faramarzi, Mohammad Ali;Mahdavi, Mohammad;Akbarzadeh, Tahmineh. And the article was included in Letters in Drug Design & Discovery in 2021.Recommanded Product: 334017-34-4 This article mentions the following:

Design and synthesis of new 5-arylisoxazole-1,3,4-thiadiazole hybrids I (R = 2-Cl, 4-Me, 3,4-(OMe)2, etc.) possessing α- glucosidase inhibitory activity were developed. Different derivatives were synthesized by the reaction of various 5-arylisoxazole-3- carboxylic acids II and Et 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)acetate. Finally, they were evaluated for their α-glucosidase inhibitory activity. It was found that Et 2-((5-(5-(2-chlorophenyl)isoxazole-3-carboxamido)-1,3,4-thiadiazol- 2-yl)thio)acetate I (R = 2-Cl) was the most potent compound (IC50 = 180.1μM) compared with acarbose as the reference drug (IC50 = 750.0μM). Also, the kinetic study of I (R = 2-Cl) revealed a competitive inhibition and docking study results indicated desired interactions of that compound with amino acid residues located close to the active site of α-glucosidase. Good α-glucosidase inhibitory activity obtained by the title compounds I introduced them as an efficient scaffold, which has merits to be considered in anti-diabetic drug discovery developments. In the experiment, the researchers used many compounds, for example, 5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4Recommanded Product: 334017-34-4).

5-(2-Chlorophenyl)-3-isoxazolecarboxylic Acid (cas: 334017-34-4) belongs to benzisoxazole derivatives. Benzisoxazoles are currently the most important building blocks in drug discovery, with a high number of positive hits encountered in biological screens of this heterocycle and its derivatives. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on. Recommanded Product: 334017-34-4

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics