Royes, Jordi; Ni, Shaofei; Farre, Albert; La Cascia, Enrico; Carbo, Jorge J.; Cuenca, Ana B.; Maseras, Feliu; Fernandez, Elena published the article 《Copper-Catalyzed Borylative Ring Closing C-C Coupling toward Spiro- and Dispiroheterocycles》. Keywords: copper catalyst borylative ring closing coupling spiro dispiroheterocycle mechanism; crystal structure mol spiroheterocyclic pendant methylene boronate preparation optimized.They researched the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8 ).Application In Synthesis of Methyl tetrahydrofuran-2-carboxylate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:37443-42-8) here.
The synthesis of spiroheterocyclic structures with a pendant methylene boronate substituent has been accomplished to promote further functionalization. A Cu-catalyzed borylative ring closing C-C coupling of an alkenyl halide is the key step toward the synthesis of [m.n]-spirocycles (m,n = 3-5). Computational studies on the mechanism reproduced all the exptl. trends and explain the enhanced reactivity of systems leading to strained smaller rings. The optimized protocol also gives access to dispirocycle scaffolds, fully characterized by x-ray diffraction.
After consulting a lot of data, we found that this compound(37443-42-8)Application In Synthesis of Methyl tetrahydrofuran-2-carboxylate can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics