Microwave-promoted synthesis of 3-amino-substituted 1,2-benzisoxazole derivatives was written by Smith, Jessica A.;Le, Giang;Jones, Eric D.;Deadman, John. And the article was included in Future Medicinal Chemistry in 2010.Electric Literature of C8H6ClNO The following contents are mentioned in the article:
1,2-Benzisoxazole derivatives have been the focus of numerous studies due to their biol. and chem. interest. The title compounds [i.e., 1,2-benzisoxazole-3-amine derivatives] were obtained by a microwave-promoted nucleophilic aromatic substitution of 3-chloro-6-methyl-1,2-benzisoxazole and 3-chloro-7-methyl-1,2-benzisoxazole with amines (54-90% yield). The above-mentioned targets included 3-(4-morpholinyl)-1,2-benzisoxazole, N-alkyl-1,2-benzisoxazol-3-amine, etc., and the product structures were confirmed by ESI, IR, NMR. The 3-chloro-1,2-benzisoxazole derivatives were also prepared by heating with microwave irradiation in quant. yields in 2 h, from the corresponding 3-hydroxy-1,2-benzisoxazole derivatives . This efficient microwave-assisted pathway could be applied to a variety of substrates in the further development of substituted 1,2-benzisoxazole derivatives This study involved multiple reactions and reactants, such as 3-Chloro-6-methylbenzo[d]isoxazole (cas: 16302-64-0Electric Literature of C8H6ClNO).
3-Chloro-6-methylbenzo[d]isoxazole (cas: 16302-64-0) belongs to benzisoxazole derivatives. Benzisoxazoles are currently the most important building blocks in drug discovery, with a high number of positive hits encountered in biological screens of this heterocycle and its derivatives. These include antidepressants, anti-inflammatory agents, antimalarial drugs, antipsychotics, antiviral agents, steroids, and anesthetics.Electric Literature of C8H6ClNO
Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics