Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 442903-28-8, is researched, SMILESS is ClC1=C(C(=O)OC)C(=CC=N1)Cl, Molecular C7H5Cl2NO2Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Organic Chemistry called Palladium-Catalyzed C-4 Selective Coupling of 2,4-Dichloropyridines and Synthesis of Pyridine-Based Dyes for Live-Cell Imaging, Author is Yang, Min; Chen, Jing; He, Chen; Hu, Xin; Ding, Yechun; Kuang, Ying; Liu, Jinbiao; Huang, Qitong, the main research direction is palladium catalyst coupling dichloropyridine boronic ester toxicity cell imaging; pyridine dye palladium catalyst coupling dichloropyridine boronic ester.Synthetic Route of C7H5Cl2NO2.
An alternative process of Pd-catalyzed C-4 selective coupling of 2,4-dichloropyridines with boronic esters was developed, which afforded 24 examples of C-4 coupled pyridines in moderate to good yields. After further arylation, 21 examples of C-2, C-4 diarylated pyridines with a significant photophys. property were obtained, which were applied as pyridine-based dyes into live-cell imaging with good biocompatibility and low toxicity.
The article 《Palladium-Catalyzed C-4 Selective Coupling of 2,4-Dichloropyridines and Synthesis of Pyridine-Based Dyes for Live-Cell Imaging》 also mentions many details about this compound(442903-28-8)Synthetic Route of C7H5Cl2NO2, you can pay attention to it, because details determine success or failure
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics