Some scientific research about 5-Fluorobenzo[d]isoxazol-3(2H)-one

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 5-Fluorobenzo[d]isoxazol-3(2H)-one, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 99822-23-8, name is 5-Fluorobenzo[d]isoxazol-3(2H)-one. In an article£¬Which mentioned a new discovery about 99822-23-8

A novel bifunctional chelating agent based on bis(hydroxamamide) for 99mTc labeling of polypeptides

This paper describes the synthesis and biological evaluation of a novel bifunctional chelating agent (BCA) based on bis(hydroxamamide) for 99mTc labeling of polypeptides. We successfully designed and synthesized C3(BHam)2¡¤COOH as a new BCA. C 3(BHam)2¡¤COOH formed a stable 99mTc complex and enabled us to prepare 99mTc-labeled polypeptides by using a 2,3,5,6-tetrafluorophenol (TFP) active ester of C3(BHam) 2¡¤COOH. 99mTc-C3(BHam) 2¡¤HSA prepared with C3(BHam)2¡¤TFP was stable in both murine plasma and an excess of l-cysteine without any dissociation of 99mTc from polypeptides. Furthermore, the blood clearance of 99mTc-C3(BHam)2¡¤HSA in mice was similar to that of 125I-HSA, suggesting that C 3(BHam)2¡¤COOH retained stable binding between 99mTc and the polypeptides in vivo. When 99mTc-C 3(BHam)2¡¤NGA was injected into mice, the radioactivity showed high hepatic uptake early on and a rapid clearance from the liver, indicating that C3(BHam)2¡¤COOH did not affect the pharmacokinetics of polypeptides in vivo and gave radiometabolites, which displayed a rapid elimination from the liver. Such characteristics would render C3(BHam)2¡¤COOH attractive as a new BCA for 99mTc labeling of polypeptides. Copyright

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics