Reference of 619-05-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 619-05-6, Name is 3,4-Diaminobenzoic acid, SMILES is O=C(O)C1=CC=C(N)C(N)=C1, belongs to benzisoxazole compound. In a article, author is Yamada, H, introduce new discover of the category.
Effect of anti-inflammatory bowel disease drug, E3040, on urate transport in rat renal brush border membrane vesicles
To confirm the assumption that 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole (E3040) acts on urate reabsorption by inhibiting urate-anion exchange at the luminal membrane of renal tubules, we investigated the inhibitory effect of E3040 and its two conjugated metabolites on hydroxyl ion (OH-) gradient-dependent urate uptake into brush border membrane vesicles from rat renal cortex and compared it with other uricosuric agents. The order of potency was AA193 (5-chloro-7,8-dihydro-3-phenylfuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid)> benzbromarone > E3040 > probenecid > E3040 sulfate > E3040 glucuronide. Furthermore, kinetic analysis revealed that E3040 may be a competitive inhibitor of the OH- gradient-dependent uptake of urate into brush border membrane vesicles. (C) 2000 Elsevier Science B.V. All rights reserved.
Reference of 619-05-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 619-05-6 is helpful to your research.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics