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Synthesis of 3-Phenyl-2,1-benzisoxazoles via Conversion of Diethyl alpha-(o-Nitroaryl)benzylphosphonates
Diethyl alpha-(o-nitroaryl)benzylphosphonates readily available via ONSH reaction upon treatment with base undergo cyclization leading to 3-phenyl-2,1-benzisoxazole in high yields. Possible route for this transformation is discussed.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics