In an article, author is Nimnual, Phongprapan, once mentioned the application of 636-61-3, Name: (R)-2-Hydroxysuccinic acid, Name is (R)-2-Hydroxysuccinic acid, molecular formula is C4H6O5, molecular weight is 134.0874, MDL number is MFCD00004245, category is Benzisoxazole. Now introduce a scientific discovery about this category.
Utility of Nitrogen Extrusion of Azido Complexes for the Synthesis of Nitriles, Benzoxazoles, and Benzisoxazoles
The utility of the nitrogen extrusion reaction of azido complexes, generated in situ from the corresponding aldehydes or ketones with TMSN3 in the presence of ZrCl4 or TfOH, has been described. These azido complexes could undergo three different pathways, depending on the substrates. First, azido methanolate complexes or imine diazonium ions could lead to benzisoxazole products via an intramolecular nucleophilic substitution. Second, imine diazonium ions could also undergo either the elimination of proton to provide nitrile products in good to excellent yields or an aryl migration, followed by an intramolecular nucleophilic addition, to give benzoxazole products in good yields.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics