Category: benzisoxazole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Methyl 2,4-dichloronicotinate, is researched, Molecular C7H5Cl2NO2, CAS is 442903-28-8, about Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange. Author is Rayner, Peter J.; Burns, Michael J.; Olaru, Alexandra M.; Norcott, Philip; Fekete, Marianna; Green, Gary G. R.; Highton, Louise A. R.; Mewis, Ryan E.; Duckett, Simon B..
Hyperpolarization turns typically weak NMR and MRI responses into strong signals so that ordinarily impractical measurements become possible. The potential to revolutionize anal. NMR and clin. diagnosis through this approach reflect this area’s most compelling outcomes. Methods to optimize the low-cost parahydrogen-based approach signal amplification by reversible exchange with studies on a series of biol. relevant nicotinamides and Me nicotinates are detailed. These procedures involve specific 2H labeling in both the agent and catalyst and achieve polarization lifetimes of ∼2 min with 50% polarization in the case of methyl-4,6-d2-nicotinate. Because a 1.5-T hospital scanner has an effective 1H polarization level of just 0.0005% this strategy should result in compressed detection times for chem. discerning measurements that probe disease. To demonstrate this technique’s generality, the authors exemplify further studies on a range of pyridazine, pyrimidine, pyrazine, and isonicotinamide analogs that feature as building blocks in biochem. and many disease-treating drugs.
As far as I know, this compound(442903-28-8)Category: benzisoxazole can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics