As a common heterocyclic compound, it belongs to benzodioxans compound, name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, and cas is 2879-20-1, its synthesis route is as follows.,2879-20-1
A mixture of Intermediate 5 (210 mg, 1.04 mmol) and 6-acetyl-l,4-benzodioxane (CAS: 2879-20-1; 223 mg, 1.25 mmol) in Ti^Pr^ (3.1 mL, 10.4 mmol) were stirred at 75 C under N2 atmosphere for 4 h. The reaction mixture was cooled to 0 C under N2 atmosphere and 1 ,2-dichloroethane (1 mL), MeOH (15 mL) and sodium boro hydride (1 18 mg, 3.13 mmol) were sequentially added. The reaction mixture was allowed to warm to rt and further stirred at rt for 3 h. Water and DCM were added. The mixture was filtered through a celite pad and the volatiles were evaporated in vacuo. The residue thus obtained was taken up in DCM and HCl (lmL, 4N in 1,4-dioxane) was added. The volatiles were evaporated in vacuo and the resulting residue was treated with Et20 to give a solid that was filtered and dried to yield product 33 as hydrochloric acid salt (29 mg, 7% yield).
With the complex challenges of chemical substances, we look forward to future research findings about 2879-20-1,belong benzodioxans compound
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose, Manuel; TRABANCO-SUAREZ, Andres, Avelino; MARTINEZ VITURRO, Carlos, Manuel; TRESADERN, Gary, John; ALCAZAR-VACA, Manuel, Jesus; (126 pag.)WO2018/109198; (2018); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem