The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Furoic hydrazide(SMILESS: O=C(C1=CC=CO1)NN,cas:3326-71-4) is researched.Recommanded Product: 35621-01-3. The article 《Investigation of DNA interaction and antiproliferative activity of mixed ligand dioxidomolybdenum(VI) complexes incorporating ONO donor aroylhydrazone ligands》 in relation to this compound, is published in Polyhedron. Let’s take a look at the latest research on this compound (cas:3326-71-4).
Four new mixed ligand dioxidomolybdenum(VI) [MoVIO2L1-3(Q)] (1-3), [MoVIO2L4(Q)]2 (H2O) (4) [where Q = MeOH for 1 and imidazole for 2-4] complexes were synthesized using four different ONO donor aroylhydrazone ligands (H2L1-4). All the derived ligands and complexes were characterized by different physicochem. techniques, i.e., elemental anal., spectroscopic methods (UV-Vis, NMR and IR), and cyclic voltammetry. The mol. geometries of 1-4 were established by X-ray crystallog. which reveals the Schiff base ligands coordinate – the distorted octahedral metal centers in a di-neg. tridentate fashion. The complexes indicated moderate binding affinity (103 to 104 M-1) towards CT-DNA. Further, in vitro cytotoxicity activity of all the complexes were determined against HT-29 (colon cancer) and HeLa (cervical cancer) cell lines. Complex 4, due to the presence of a heterocyclic 2-hydroxy-1-naphthyl moiety in the ligand backbone, was found to be more biol. active in comparison to the others in the series.
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics