Tag: 212.0433

Discovery of novel 3-{[(5,5-dimethyl-4,5-dihydroisoxazol-3-yl)sulfonyl]methyl}benzo[d]isoxazole analogs as promising very long chain fatty acids inhibitors was written by Lin, Jian;Li, Yitao;Hu, Xiaoyun;Chi, Weilin;Zeng, Shuiming;Xu, Junxing. And the article was included in Journal of Heterocyclic Chemistry in 2021.Category: benzisoxazole This article mentions the following:

In order to explore and find novel VLCFAs inhibitors with higher herbicidal activity and improved crop safety, a variety of new I [R¹ = H, F; R² = H, F Cl, Br; R³ = H, F, Br] were reasonably designed and synthesized. The results of greenhouse experiments indicated that several compounds exhibited good herbicidal activity against Digitaria sanguinalis, Echinochloa crus-galli, and Setaria faberii at rates of 150 g ai/ha. Compounds I [R¹ = F, R² = R³ = H] and II [R¹ = R³ = H, R² = F] displayed promising herbicidal activity against D sanguinalis and E crus-galli at rates of 75 g ai/ha, which is better than com. pyroxasulfone and S-metolachlor. Moreover, compound II [R¹ = R³ = H, R² = F] displayed higher activity against E crus-galli, D sanguinalis, and S faberii than pyroxasulfone and S-metolachlor even at a rate of 37.5 and 18.75 g ai/ha. Furthermore, both of the compounds I [R¹ = F, R² = R³ = H] and II [R¹ = R³ = H, R² = F] were much safer to these tested crops, especially to rice, wheat and rape, at the rate of 150 g ai/ha than pyroxasulfone. Therefore, II [R¹ = R³ = H, R² = F] may act as a new lead structure for novel herbicides discovery. In the experiment, the researchers used many compounds, for example, 7-Bromo-3-methylbenzo[d]isoxazole (cas: 66033-75-8Category: benzisoxazole).

7-Bromo-3-methylbenzo[d]isoxazole (cas: 66033-75-8) belongs to benzisoxazole derivatives. Benzisoxazole is an aromatic organic compound containing a benzene-fused isoxazole ring structure. It has reactive sites which allow for functionalization. Functionalized benzisoxazoles and benzisoxazoyls have a variety of uses, including pharmaceutical drugs such as some antipsychotics and the anticonvulsant zonisamide.Category: benzisoxazole

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

A modified method for the synthesis of 1,2-benzisoxazoles was written by Thakar, K. A.;Goswami, D. D.;Bhawal, B. M.. And the article was included in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 1977.Recommanded Product: 7-Bromo-3-methylbenzo[d]isoxazole This article mentions the following:

Thirty-five substituted 1,2-benzisoxazoles (e.g. 3-methyl-, 3,5,7-trimethyl-6-chloro-3-ethyl-, etc.) were prepared in 85-100% yields by cyclizing o-hydroxyaryl ketoxime acetates in refluxing pyridine. Some of the benzisoxazoles exhibit antifungal activity (no data). In the experiment, the researchers used many compounds, for example, 7-Bromo-3-methylbenzo[d]isoxazole (cas: 66033-75-8Recommanded Product: 7-Bromo-3-methylbenzo[d]isoxazole).

7-Bromo-3-methylbenzo[d]isoxazole (cas: 66033-75-8) belongs to benzisoxazole derivatives. Many fluorinated compounds, 1,2-benzisoxazole derivatives and various amides are currently used in the treatment of diseases. The benzisoxazole template forms the molecular backbone, possesses versatile binding properties with a frequently occurring binding motif, and provides potent and selective ligands for a range of different biological targets in medicinal chemistry.Recommanded Product: 7-Bromo-3-methylbenzo[d]isoxazole

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics