So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Khoje, Abhijit Datta; Gundersen, Lise-Lotte researched the compound: Methyl 2,4-dichloronicotinate( cas:442903-28-8 ).COA of Formula: C7H5Cl2NO2.They published the article 《Reactivity and regioselectivity in Stille couplings of 3-substituted 2,4-dichloropyridines》 about this compound( cas:442903-28-8 ) in Tetrahedron Letters. Keywords: Stille coupling furyltributyltin dichloropyridine regioselectivity. We’ll tell you more about this compound (cas:442903-28-8).
The influence of substituents at C-3 of 2,4-dichloropyridines on their reactivity and regioselectivity in Pd-catalyzed cross-couplings is studied. As a model reaction, the (Ph3P)2PdCl2-catalyzed Stille coupling between 2-furyl(tributyl)tin and pyridines is chosen. Increased electron-withdrawing ability of a substituent at the pyridine 3-position improves the overall reactivity. Absolute selectivity for coupling at C-2 is achieved with an amino group at C-3, and the selectivity is totally reversed when the amino group is exchanged for a nitro substituent.
This literature about this compound(442903-28-8)COA of Formula: C7H5Cl2NO2has given us a lot of inspiration, and I hope that the research on this compound(Methyl 2,4-dichloronicotinate) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics