Zhang, Yinjun; Cheng, Feifei; Yan, Hongde; Zheng, Jianyong; Wang, Zhao published the article 《The enzymatic resolution of 1-(4-chlorophenyl)ethylamine by Novozym 435 to prepare a novel triazolopyrimidine herbicide》. Keywords: Novozym 435 triazolopyrimidine herbicide; 1-(4-chlorophenyl)ethylamine; Novozym 435; amidation; lipase; resolution.They researched the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8 ).Recommanded Product: Methyl tetrahydrofuran-2-carboxylate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:37443-42-8) here.
The kinetic resolution of (R,S)-1-(4-chlorophenyl)ethylamine was accomplished using a com. lipase from Candida antarctica (Novozym 435). The performance of this lipase was investigated for the enantioselective amidation of (R,S)-1-(4-chlorophenyl)ethylamine, leaving the target product (S)-1-(4-chlorophenyl)ethylamine in its unreacted form. The effects of various types of solvents and an acyl donor, the molar ratio of the substrate to the acyl donor, and the reaction temperature were studied. The optimum reaction conditions were found to result in amidation with Me 2-tetrahydrofuroate at 40°C in Me tert-Bu ether, with a substrate/acyl donor molar ratio of 1:2.4. The conversion rate of (R,S)-1-(4-chlorophenyl)ethylamine was 52%, with an enantiomeric excess of 99% towards the unreacted substrate in a reaction time of 22 h. Finally, using optically pure (S)-1-(4-chlorophenyl)ethylamine as the raw material, the chem. synthesis of (S)-N-(1-(4-chlorphenyl)ethyl)-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)acetamide, a novel triazolopyrimidine herbicide, was achieved, and the total yield and purity were 83.5% and 95.3%, resp.
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Benzisoxazole – Wikipedia,
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