Let¡¯s face it, organic chemistry can seem difficult to learn, Product Details of 99189-60-3, Especially from a beginner¡¯s point of view. Like 99189-60-3, Name is 2-[1-(2-Amino-2-oxoethyl)cyclohexyl]acetic Acid, molecular formula is Benzisoxazole, belongs to Benzisoxazole compound. In a document, author is Otley, Kate D., introducing its new discovery.
A Lewis Acid Catalyzed Annulation to 2,1-Benzisoxazoles
We report here a new, atom economical annulation to 2,1-benzisoxazole scaffolds via the BF3 center dot Et2O-catalyzed reaction of glyoxylate esters and nitrosoarenes. The developed method represents a convergent route to this compound class from previously unexplored inputs and provides a range of 2,1-benzisoxazoles in moderate to high yields under convenient conditions. Along with exploration of substrate scope, initial mechanistic investigation through O-18 labeling and the synthesis of a reaction intermediate provides evidence for an unusual umpolung addition of glyoxylates to nitrosobenzenes with high O-selectivity, followed by a new type of Friedel-Crafts cyclization.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics