In 2020 INORG CHIM ACTA published article about TRANSITION-METAL-COMPLEXES; ALKALINE-PHOSPHATASE; CRYSTAL-STRUCTURES; DNA-BINDING; SPECTROSCOPIC CHARACTERIZATION; INDOLE-2-CARBOXYLIC ACID; ENZYME-INHIBITION; ZN(II); LIGAND; DRUG in [Naz, Saba; Uddin, Noor; Ullah, Kaleem; Haider, Ali; Ali, Saqib] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan; [Gul, Amna; Faisal, Sulaiman; Nadhman, Akhtar] CECOS Univ, Dept Biotechnol, Inst Integrat Biosci, Peshawar, Pakistan; [Bibi, Memoona; Yousuf, Sammer] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan in 2020, Cited 77. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7. Safety of 2-Phenylbutanoic acid
A series of five new zinc(II) complexes of 2-phenylbutyric acid comprising of one homoleptic (1) and four heteroleptic (2-5) complexes were synthesized under open beaker conditions. The behavior of the complexes in the solid and solution state was explored through FT-IR and NMR (H-1 and C-13) spectroscopy, respectively. Crystallographic data have revealed that complexes 2 and 3 crystallized in monoclinic and triclinic crystal system, respectively, with a distorted octahedral geometry, whereas complex 4 crystallized in monoclinic crystal system with a pentagonal geometry around the zinc(II) atom. All the complexes have been screened for enzyme (alkaline phosphatase) inhibition, in vitro hemolysis and antileishmanial activity, DNA and cetyl-trimethylammonium bromide (CTAB) interaction. The increase in the concentration of complexes 1, 2, 4 and 5 remarkably decreases the activity of enzyme alkaline phosphatase, whereas complex 3 was found inactive. The behavior of the complexes as a potent drug is clear from the results of hemolysis and antileishmanial activity against promastigote. The UV-Vis spectroscopic data of complexes-DNA interactions suggested a surface binding mode whereas the interaction of CTAB with complexes, studied through conductometry, confirmed strong in-teracting ability of complexes with CTAB.
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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics