Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tetrahedron Letters called Reactivity and regioselectivity in Stille couplings of 3-substituted 2,4-dichloropyridines, Author is Khoje, Abhijit Datta; Gundersen, Lise-Lotte, which mentions a compound: 442903-28-8, SMILESS is ClC1=C(C(=O)OC)C(=CC=N1)Cl, Molecular C7H5Cl2NO2, Quality Control of Methyl 2,4-dichloronicotinate.
The influence of substituents at C-3 of 2,4-dichloropyridines on their reactivity and regioselectivity in Pd-catalyzed cross-couplings is studied. As a model reaction, the (Ph3P)2PdCl2-catalyzed Stille coupling between 2-furyl(tributyl)tin and pyridines is chosen. Increased electron-withdrawing ability of a substituent at the pyridine 3-position improves the overall reactivity. Absolute selectivity for coupling at C-2 is achieved with an amino group at C-3, and the selectivity is totally reversed when the amino group is exchanged for a nitro substituent.
Although many compounds look similar to this compound(442903-28-8)Quality Control of Methyl 2,4-dichloronicotinate, numerous studies have shown that this compound(SMILES:ClC1=C(C(=O)OC)C(=CC=N1)Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics