Research speed reading in 2021. Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. Related Products of 75-98-9, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. 75-98-9, Name is Pivalic acid, molecular formula is C5H10O2. In an article, author is Lee, SY,once mentioned of 75-98-9.
Acetylcholinesterase (AChE) is an important cholinergic marker of Alzheimer’s disease (AD) and shows reduced activity in postmortem AD brain tissues. 1-(4-Fluorobenzyl)-4-[(5,6-dimethoxy-l-oxoindan-2-fluoro-2-yl)methyl]piperidine (G379, 1), an AChE inhibitor with a subnanomolar IC50 (0.56 nM), was prepared as a F-18-labeled radioligand ([F-18]1) and evaluated in mice. Metabolism studies of [F-18]1 showed no metabolites in the mouse brain. Tissue distribution studies demonstrated its uniform regional distribution in the mouse brain, suggesting that this radioligand is not suitable for the in vivo imaging of AChE. This result along with reports on radiolabeled AT-benzylpiperidine lactam benzisoxazole (IC50 < 1 nM) and other radiolabeled benzylpiperidme derivatives (IC50 > 1 nM) suggested that a subnanornolar IC50 may not be the only important factor in determining the suitability of a radioligand for in Vivo Studies of AChE. (c) 2006 Elsevier Inc. All rights reserved.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 75-98-9. Related Products of 75-98-9.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics