Chemical Research Letters, May 2021. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. 181289-15-6, Name is 3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid, molecular formula is C9H17NO3, COA of Formula: https://www.ambeed.com/products/181289-15-6.html, belongs to benzisoxazole compound, is a common compound. In a patnet, author is Solanki, Pavankumar V., once mentioned the new application about 181289-15-6.
The present work describes an improved and efficient process for the synthesis of paliperidone (1), an antipsychotropic agent. The synthesis comprises the DBU (1,8-diazabicycloundec-7-ene) catalyzed N-alkylation of 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]-pyrimidin-4-one (5) with 6-fluoro-3-piperidin-4-yl-1,2 benzisoxazole hydrochloride (6) in methanol as the solvent and diisopropylamine as a base to yield paliperidone (1) with 85% yield and over 97% purity by HPLC. The present work also describes an industrially efficient purification process for the removal of critical process related impurities (8 and 9) in paliperidone (1). The process furnished 1 with an overall yield of about 60% and 99.85% purity.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 181289-15-6, COA of Formula: https://www.ambeed.com/products/181289-15-6.html.
Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics