Product Details of 3326-71-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis, crystal structure, DNA/bovine serum albumin binding and antitumor activity of two transition metal complexes with 4-acylpyrazolone derivative. Author is Zhang, Yan-Ping; Li, Yue; Xu, Guan-Cheng; Li, Jin-Yu; Luo, Hua-Ying; Li, Jin-Yao; Zhang, Li; Jia, Dian-Zeng.
Two new complexes, namely [Cu6L6] (1) and [Zn(HL)2] (2) (H2L = N-(1-phenyl-3-methyl-4-propenylidene-5-pyrazolone)-2-furancarboxylic acid hydrazide), have been synthesized and characterized. Single crystal x-ray anal. indicates that complex 1 has a hexanuclear structure and complex 2 exhibits a mononuclear structure. The DNA/bovine serum albumin (BSA) binding properties of 1 and 2 were investigated by absorption spectroscopy and fluorescence quenching. Both complexes could effectively intercalate to DNA with calculated quenching constants of 2.6 × 105 and 1.25 × 105 M-1, resp. The quenching mechanism of the intrinsic fluorescence of BSA by the complexes is a static one. The cytotoxicities of 1 and 2 were investigated in two human tumor cell lines, human esophageal cancer cells (Eca-109) and cervical cancer cells (HeLa). Complex 1 exhibits higher antitumor activity than 2. Furthermore, 1 can inhibit HeLa cells by inducing apoptosis and G0/G1 phase cell cycle arrest. All results demonstrate that 1 and 2 both have DNA/BSA binding capacity and antitumor activity.
There is still a lot of research devoted to this compound(SMILES：O=C(C1=CC=CO1)NN)Product Details of 3326-71-4, and with the development of science, more effects of this compound(3326-71-4) can be discovered.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics