Zhou, Wu-Xi; Chen, Chen; Liu, Xiao-Qin; Li, Ying; Kong, Ling-Yi; Luo, Jian-Guang published the artcile< Synthesis and biological evaluation of novel withangulatin A derivatives as potential anticancer agents>, Recommanded Product: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole, the main research area is withangulatin A derivative preparation anticancer structure activity; Anticancer; Apoptosis; Cell cycle; Reactive oxygen species; Withangulatin A derivatives.
Novel withangulatin A (WA) derivatives were synthesized and evaluated for antiproliferative activity against four human cancer cell lines (U2OS, MDA-MB-231, HepG2, and A549). Among these derivatives, I exhibited the most potent antiproliferative activity, with an IC50 value of 74.0 nM against the human breast cancer cell line MDA-MB-231 and potency that was 70-fold that of WA (IC50 = 5.22μM). Moreover, I caused G2-phase cell cycle arrest in a concentration-dependent manner and induced the apoptosis of MDA-MB-231 cells by increasing intracellular reactive oxygen species (ROS). Compound I showed a high selectivity index (SI = 267.03) for breast cancer MDA-MB-231 cells. These results suggest that I is a promising anticancer agent.
Bioorganic Chemistry published new progress about Anti-apoptotic agents. 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Recommanded Product: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole.
Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics